\documentclass{article}
\begin{document}

\begin{tabular}{lcc@{\hskip 0.5in}cc}
	       & \multicolumn{1}{c}{(1)} & \multicolumn{1}{c@{\hskip 0.5in}}{(2)} & \multicolumn{1}{c}{(3)} & \multicolumn{1}{c}{(4)} \\
	Line 1 & One                     & Two                                    & Three                   & Four                    \\
	Line 2 & Five                    & Six                                    & Seven                   & Eight
\end{tabular}

\begin{tabular}{lcc@{\hskip 0.5in}cc}
	       & \multicolumn{1}{c}{(1)} & \multicolumn{2}{c@{\hskip 0.5in}}{(2)} & \multicolumn{1}{c}{(3)} & \multicolumn{1}{c}{(4)} \\
	Line 1 & One                     & Two & Three                            & Four                                              \\
	Line 2 & Five                    & Six & Seven                            & Eight
\end{tabular}

\begin{tabular}{lcc@{\hskip 0.5in}cc}
	       & \multicolumn{1}{c}{(1)} & \multicolumn{3}{c@{\hskip 0.5in}}{(2)} & \multicolumn{1}{c}{(3)} & \multicolumn{1}{c}{(4)} \\
	Line 1 & One                     & Two & Three & Four                                                                         \\
	Line 2 & Five                    & Six & Seven & Eight
\end{tabular}

\begin{tabular}{lcc@{\hskip 0.5in}cc}
	       & \multicolumn{2}{c}{(1)} & \multicolumn{1}{c@{\hskip 0.5in}}{(2)} & \multicolumn{1}{c}{(3)} & \multicolumn{1}{c}{(4)} \\
	Line 1 & One  & Two              & Three                                  & Four                                              \\
	Line 2 & Five & Six              & Seven                                  & Eight
\end{tabular}

\begin{tabular}{lcc@{\hskip 0.5in}cc}
	       & \multicolumn{3}{c}{(1)} & \multicolumn{1}{c@{\hskip 0.5in}}{(2)} & \multicolumn{1}{c}{(3)} & \multicolumn{1}{c}{(4)} \\
	Line 1 & One  & Two & Three      & Four                                                                                       \\
	Line 2 & Five & Six & Seven      & Eight
\end{tabular}

\begin{tabular}{lcc@{\hskip 0.5in}cc}
	       & \multicolumn{4}{c}{(1)}    & \multicolumn{1}{c@{\hskip 0.5in}}{(2)} & \multicolumn{1}{c}{(3)} & \multicolumn{1}{c}{(4)} \\
	Line 1 & One  & Two & Three & Four                                                                                               \\
	Line 2 & Five & Six & Seven & Eight
\end{tabular}

\begin{tabular}{lcc@{\hskip 0.5in}cc}
	       & \multicolumn{1}{c}{(1)} & \multicolumn{1}{c@{\hskip 0.5in}}{(2)} & \multicolumn{1}{c}{(3)} & \multicolumn{3}{c}{(4)} \\
	Line 1 & One                     & Two                                    & Three                   & Four                    \\
	Line 2 & Five                    & Six                                    & Seven                   & Eight
\end{tabular}

\begin{tabular}{lcc@{\hskip 0.5in}cc}
	       & (1)  & (2) & (3)   & (4)   \\
	Line 1 & One  & Two & Three & Four  \\
	Line 2 & Five & Six & Seven & Eight
\end{tabular}

\end{document}
